Kutlu A, Bozkanat E, Ciftçi Fi, Bozkurt B, Gorur R, Ardiç N, Taskapan O
Department of Allergy, Gulhane Military Medical Academy, Haydarpasa Teaching Hospital, Istanbul, Turkey.
J Investig Allergol Clin Immunol. 2008;18(2):113-8.
Mycobacterium tuberculosis has been shown to suppress allergic airway disease driven by type 2 helper T cells in animal models. In this study, we investigated the effect of active tuberculosis on skin prick test (SPT) positivity and serum immunoglobulin (Ig) E levels of atopic patients with and without tuberculosis infection.
Seventeen atopic HIV-negative men with pulmonary tuberculosis and 18 atopic healthy male controls at our military hospital were studied prospectively between March 2005 and March 2006. The sums of all SPT positive tests and positivity to house dust mite alone were calculated before initiation of treatment and after 6 months. Measurement of total serum IgE levels was also performed at the same moments.
The mean (SD) initial serum total IgE concentrations were significantly higher in the tuberculosis patients than in the healthy controls (324.1 [317.67] U/mL vs. 146.7 [75.29] U/mL, respectively; P < .05), The total serum IgE concentrations after 6 months of treatment were also higher in the patients than in the controls. The mean sum of SPT positivity was higher in the tuberculosis patients than in the controls at both testing times.
Our study does not support the hypothesis that M tuberculosis suppresses atopy and atopic disorders, but large, prospective experimental studies are needed before excluding the possibility of a relationship.
在动物模型中，已证实结核分枝杆菌可抑制由2型辅助性T细胞驱动的过敏性气道疾病。在本研究中，我们调查了活动性结核病对有或无结核感染的特应性患者皮肤点刺试验（SPT）阳性率和血清免疫球蛋白（Ig）E水平的影响。
2005年3月至2006年3月期间，对我院17名患有肺结核的特应性HIV阴性男性和18名特应性健康男性对照进行了前瞻性研究。在开始治疗前和6个月后，计算所有SPT阳性试验的总和以及仅对屋尘螨的阳性率。同时也在相同时间点测量血清总IgE水平。
肺结核患者的平均（标准差）初始血清总IgE浓度显著高于健康对照（分别为324.1[317.67]U/mL和146.7[75.29]U/mL；P<.05），治疗6个月后患者的血清总IgE浓度也高于对照。在两个检测时间点，肺结核患者的SPT阳性率总和均高于对照。
我们的研究不支持结核分枝杆菌抑制特应性和特应性疾病这一假说，但在排除两者之间存在关联的可能性之前，还需要进行大规模的前瞻性实验研究。
