Defilippi C, Gómez E, Chesta J
Departamento de Fisiología, Facultad de Medicina, Universidad de Chile, Santiago.
Rev Med Chil. 1991 Jul;119(7):739-43.
Infusion of hyperosmotic solutions into the duodenum lead to increased motility. To investigate the mechanism of this effect, 9 healthy volunteers received small infusions of hypertonic (1250 mOsm/kg) NaCl or glucose. Intestinal motility was registered using manometric system with multiple lumens 3 cm apart. Nineteen glucose infusions did not modify intestinal motility. Of 43 NaCl infusions, motility was increased in 24, 7 of them with a typical migratory complex, phase III. In 17 cases, non propagated contractions increasing in a cephalo-caudal direction were noted. The latter may be related to delayed gastric emptying associated to hyperosmotic loads.
向十二指肠输注高渗溶液会导致蠕动增加。为了研究这种效应的机制，9名健康志愿者接受了少量高渗（1250 mOsm/kg）氯化钠或葡萄糖输注。使用相距3厘米的多腔测压系统记录肠道蠕动。19次葡萄糖输注未改变肠道蠕动。在43次氯化钠输注中，24次蠕动增加，其中7次出现典型的移行性复合波Ⅲ期。在17例中，观察到非传播性收缩沿头-尾方向增加。后者可能与高渗负荷相关的胃排空延迟有关。
