Shirazi S, Schulze-Delrieu K, Brown C K
Gastroenterology Research Laboratories, Veterans Administration Medical Center, Iowa City, IA
J Lab Clin Med. 1988 Jun;111(6):654-60.
Experiments were conducted to determine to what extent the duodenum resists the emptying of various solutions from the isolated stomach. Cat stomachs were maintained in Krebs solution in vitro, and filled with 100 ml isotonic saline solution, isotonic glucose, hypertonic saline solution, hypertonic glucose, or dilute acid. Gastric pressure was constantly monitored; gastric output was collected constantly by a cannula in the proximal or distal duodenum. For all solutions, cumulative gastric output at all times was considerably less with the distal than the proximal cannula position. This difference was almost entirely caused by a smaller fractional gastric output during the first minute of gastric emptying, and by reduced amplitude of the gastric stroke volume with the distal cannula position. Some differences were observed in the gastric emptying rate for the various solutions; isotonic saline solution emptied particularly slowly and hydrochloric acid emptied particularly fast. In addition, the various solutions produced different gastric pressure patterns, which could not be entirely explained by differences in residual gastric volume. We concluded that the cat duodenum provides a resistance to gastric emptying over and above that generated by the pylorus, and that the duodenal resistance is caused by limitations in duodenal capacity. It is furthermore concluded that the mechanical activity of the isolated stomach and duodenum is affected by the chemical composition of their luminal contents.
进行了实验以确定十二指肠对离体胃中各种溶液排空的抵抗程度。将猫的胃在体外置于 Krebs 溶液中，并用 100 毫升等渗盐水溶液、等渗葡萄糖、高渗盐水溶液、高渗葡萄糖或稀酸填充。持续监测胃内压力；通过十二指肠近端或远端的插管持续收集胃排出物。对于所有溶液，在所有时间点，使用远端插管时的累积胃排出量明显少于近端插管时的。这种差异几乎完全是由于胃排空第一分钟内胃排出量的分数较小，以及远端插管位置时胃冲程容积的幅度减小所致。观察到各种溶液的胃排空速率存在一些差异；等渗盐水溶液排空特别缓慢，盐酸排空特别快。此外，各种溶液产生了不同的胃内压力模式，这不能完全用残余胃容积的差异来解释。我们得出结论，猫的十二指肠对胃排空的抵抗作用超过幽门产生的抵抗作用，并且十二指肠的抵抗是由十二指肠容量的限制引起的。此外还得出结论，离体胃和十二指肠的机械活动受其腔内内容物化学成分的影响。
