Galleguillos V, Rodríguez M I, Bronfman L, Niklitscheck E, Silva M, Soto J R
Departamento de Medicina Interna, Facultad de Medicina, Universidad de Chile (Divisíon Occidente), Hospital San Juan de Dios, Santiago.
Rev Med Chil. 1991 Jul;119(7):789-92.
POEMS (acronym for polyneuropathy, organomegaly, endocrinopathy, M protein and skin changes) is a very rare syndrome probably related to plasma cell dyscrasia. A 43 year old man developed a progressive symmetric sensory motor polyneuropathy 2 years before admission. Hepatosplenomegaly and sclerodermatoid skin changes were present on physical examination. A sclerotic lesion of the right femur was disclosed by radiologic examination. Serum immunoelectrophoresis demonstrated a monoclonal protein IgG-lambda pattern and the bone marrow biopsy revealed an increased plasma cell count (15%). The patient died 7 months after admission from pneumonia. A review of the literature is included.
POEMS综合征（多发性神经病、器官肿大、内分泌病、M蛋白和皮肤改变的首字母缩写）是一种非常罕见的综合征，可能与浆细胞异常增殖有关。一名43岁男性在入院前2年出现进行性对称性感觉运动性多发性神经病。体格检查发现肝脾肿大和硬皮病样皮肤改变。放射学检查发现右股骨有硬化性病变。血清免疫电泳显示单克隆蛋白IgG-λ型，骨髓活检显示浆细胞计数增加（15%）。患者入院7个月后死于肺炎。本文还包括文献综述。
