源自人类白血病的连续细胞培养物所释放的一种抗原在人类骨髓中的出现。
Occurrence in human bone marrows of an antigen released from continuous cell cultures derived from human leukemia.
作者信息
Smith C C, Maverakis N H, Dabich L, Ackermann W W
出版信息
Proc Soc Exp Biol Med. 1976 Sep;152(4):651-5. doi: 10.3181/00379727-152-39460.
Fluorescent antibodies prepared against extracellular particles from a continuous culture of cells derived from a monocytic leukemia stained JIII cells but not cells infected with Rauscher leukemia virus or simian sarcoma virus. These antibodies reacted with 38% of bone marrow preparations from patients with lymphoma, 26% of preparations from patients with nonmalignant blood disorders and 6% of preparations from patients with leukemia. Bone marrow films from patients with lymphoma over the age of 50 stained less frequently than those from patients under 50. These particles released from JIII cells are not antigenically related to two of the commonly studied oncornaviruses, but may be indicative of the etiology or disease process of lymphoma in young patients.
针对源自单核细胞白血病的细胞连续培养物的细胞外颗粒制备的荧光抗体，可使JIII细胞染色，但不能使感染劳斯氏白血病病毒或猿猴肉瘤病毒的细胞染色。这些抗体与淋巴瘤患者骨髓标本的38%、非恶性血液疾病患者标本的26%以及白血病患者标本的6%发生反应。50岁以上淋巴瘤患者的骨髓涂片染色频率低于50岁以下患者。从JIII细胞释放的这些颗粒与两种常见研究的肿瘤病毒没有抗原相关性，但可能指示年轻患者淋巴瘤的病因或疾病进程。
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