Castrillón M, Palma I, Azócar G, Tapia R, Silva A, Pescio S, Aguayo R, Triantafilo V, Contreras J, Thompson L
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad de Chile.
Rev Med Chil. 1991 Aug;119(8):913-6.
Forty females (ages 15-74) with community-acquired, uncomplicated urinary tract infections were studied. Clinical and microbiological efficacy of cefuroxime (250 mg td) and trimethoprim sulfamethoxazole (160/800 mg td) used for 7 days were evaluated. The microorganisms found in the pre-treatment urinary cultures were: Escherichia Coli (85%), Klebsiella Pneumoniae (12.5%), and E. Agglomerans (2.5%). They were all susceptible to cefuroxime, and 42.5% were resistant to trimethoprim sulfamethoxazole (Kirby-Bauer). These findings show that trimethoprim sulfamethoxazole should not be used empirically while waiting for the results of urinary cultures, and that cefuroxime is a good alternative in these cases. Clinical cure was observed in all, and bacteriological cure in 75% of the pts treated with both antimicrobial agents. Relapses and reinfections were detected during follow-up emphasizing the importance of intra and post-treatment urinary cultures.
对40名年龄在15 - 74岁之间、患有社区获得性非复杂性尿路感染的女性进行了研究。评估了头孢呋辛（250毫克，每日两次）和复方磺胺甲恶唑（160/800毫克，每日两次）连续使用7天的临床和微生物学疗效。治疗前尿液培养中发现的微生物有：大肠杆菌（85%）、肺炎克雷伯菌（12.5%）和成团泛菌（2.5%）。它们对头孢呋辛均敏感，而对复方磺胺甲恶唑耐药的占42.5%（Kirby - Bauer法）。这些结果表明，在等待尿液培养结果期间不应经验性使用复方磺胺甲恶唑，而头孢呋辛在这些病例中是一个很好的替代选择。使用这两种抗菌药物治疗的患者全部实现了临床治愈，75%实现了细菌学治愈。随访期间检测到复发和再感染情况，强调了治疗期间及治疗后尿液培养的重要性。
