首发精神分裂症患者抗精神病药物治疗的依从性、复发及再次住院情况
Non-adherence to antipsychotic medication, relapse and rehospitalisation in recent-onset schizophrenia.
作者信息
Morken Gunnar, Widen Jan H, Grawe Rolf W
机构信息
Department of Neuroscience, Faculty of Medicine, NTNU, N-7006 Trondheim, Norway.
出版信息
BMC Psychiatry. 2008 Apr 30;8:32. doi: 10.1186/1471-244X-8-32.
BACKGROUND
The aims of this study were to describe outcome with respect to persistent psychotic symptoms, relapse of positive symptoms, hospital admissions, and application of treatment by coercion among patients with recent onset schizophrenia being adherent and non-adherent to anti-psychotic medication.
MATERIALS AND METHODS
The study included 50 patients with recent onset schizophrenia, schizoaffective or schizophreniform disorders. The patients were clinically stable at study entry and had less than 2 years duration of psychotic symptoms. Good adherence to antipsychotic medication was defined as less than one month without medication. Outcomes for poor and good adherence were compared over a 24-month follow-up period.
RESULTS
The Odds Ratio (OR) of having a psychotic relapse was 10.27 and the OR of being admitted to hospital was 4.00 among non-adherent patients. Use of depot-antipsychotics were associated with relapses (OR = 6.44).
CONCLUSION
Non-adherence was associated with relapse, hospital admission and having persistent psychotic symptoms. Interventions to increase adherence are needed.
TRIAL REGISTRATION
Current Controlled Trials NCT00184509. Key words: Adherence, schizophrenia, antipsychotic medication, admittances, relapse.
背景
本研究旨在描述近期发病的精神分裂症患者中，坚持和不坚持使用抗精神病药物的患者在持续性精神病症状、阳性症状复发、住院情况以及强制治疗应用方面的结果。
材料与方法
该研究纳入了50例近期发病的精神分裂症、精神分裂症样情感障碍或精神分裂症样障碍患者。患者在研究开始时临床稳定，精神病症状持续时间少于2年。对抗精神病药物的良好依从性定义为停药时间少于1个月。在24个月的随访期内比较了依从性差和依从性好的患者的结果。
结果
在不依从的患者中，精神病复发的优势比（OR）为10.27，住院的OR为4.00。使用长效抗精神病药物与复发相关（OR = 6.44）。
结论
不依从与复发、住院以及持续性精神病症状有关。需要采取干预措施来提高依从性。
试验注册
当前对照试验NCT00184509。关键词：依从性、精神分裂症、抗精神病药物、住院、复发。
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