Kinetics of histone protein glycation.

The kinetics of glycation of histone proteins was studied. The glucose uptake of H1 linker histone reached saturation attained after an exponential course. H2-H4 core histone and total histone exhibited two-phase courses differing in time. With the uptake of glucose, the electromobility of the fractions changed. The kinetic results are explained in terms of interaction between proteins.