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物理治疗师指导的盆底肌肉训练能否降低前列腺癌根治术后的尿失禁发生率?一项随机对照试验。

Does physiotherapist-guided pelvic floor muscle training reduce urinary incontinence after radical prostatectomy? A randomised controlled trial.

作者信息

Overgård Mari, Angelsen Anders, Lydersen Stian, Mørkved Siv

机构信息

Clinical Service, St. Olavs Hospital, Trondheim University Hospital, Norway.

出版信息

Eur Urol. 2008 Aug;54(2):438-48. doi: 10.1016/j.eururo.2008.04.021. Epub 2008 Apr 18.

Abstract

BACKGROUND

Urinary incontinence after radical prostatectomy (RP) is a common problem and may lead to reduced quality of life.

OBJECTIVE

To assess the effects of guided pelvic floor muscle training on continence status and perceived problems with urinary function after RP.

DESIGN, SETTING, AND PARTICIPANTS: We conducted a randomised controlled trial at St. Olavs Hospital/Trondheim University Hospital in Norway between September 2005 and December 2007. All men with clinically localised prostate cancer who underwent surgery with open RP were invited to participate, until 85 participants were included. Dropout rate was 6%.

INTERVENTION

Two intervention groups (A and B). Both groups received instructions in correct pelvic floor muscle contractions and were encouraged to train the pelvic floor muscles. Group A was offered additional follow-up training instructions by a physiotherapist throughout the 1-yr period.

MEASUREMENTS

Primary outcome was continence (0 pads) status, and secondary outcomes were perceived problems with urinary function 6 wk and 3, 6, and 12 mo postoperatively.

RESULTS

No statistically significant difference in continence status between groups was found at 3 mo; 46% were continent in group A versus 43% in group B (p=0.73). In group A, 97% reported no or only mild problems with urinary function compared to 78% in group B (p=0.010). After 6 mo there was a clinically relevant difference in continence status between groups: 79% were continent in group A and 58% in group B (p=0.061). Twelve months postsurgery the difference was clinically and statistically significant (p=0.028) in favour of group A; 92% were continent in group A and 72% in group B.

CONCLUSIONS

Continence rates were similar 3 mo after RP in groups performing intensive pelvic floor muscle training with or without follow-up instructions by a physiotherapist. However, in the following period up to 1 yr, the group receiving physiotherapist-guided training reduced urinary incontinence significantly more compared to patients training on their own.

摘要

背景

根治性前列腺切除术后尿失禁是一个常见问题,可能导致生活质量下降。

目的

评估指导性盆底肌训练对根治性前列腺切除术后控尿状态及尿功能相关问题的影响。

设计、地点和参与者:2005年9月至2007年12月期间,我们在挪威特隆赫姆大学医院圣奥拉夫斯医院进行了一项随机对照试验。邀请所有接受开放性根治性前列腺切除术的临床局限性前列腺癌男性参与,直至纳入85名参与者。失访率为6%。

干预措施

两个干预组(A组和B组)。两组均接受正确盆底肌收缩的指导,并被鼓励训练盆底肌。A组在1年期间由物理治疗师提供额外的随访训练指导。

测量指标

主要结局是控尿(使用0片尿垫)状态,次要结局是术后6周、3个月、6个月和12个月时感知到的尿功能问题。

结果

3个月时,两组之间的控尿状态无统计学显著差异;A组46%的患者控尿,B组为43%(p = 0.73)。A组中,97%的患者报告尿功能无问题或仅有轻微问题,而B组为78%(p = 0.010)。6个月后,两组之间的控尿状态存在临床相关差异:A组79%的患者控尿,B组为58%(p = 0.061)。术后12个月,差异在临床和统计学上均有显著意义(p = 0.028),有利于A组;A组92%的患者控尿,B组为72%。

结论

在进行强化盆底肌训练的组中,无论有无物理治疗师的随访指导,根治性前列腺切除术后3个月时的控尿率相似。然而,在接下来长达1年的时间里,接受物理治疗师指导训练的组与自行训练的患者相比,尿失禁减少得更为显著。

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