Gou Maling, Li Xingyi, Dai Mei, Gong Changyang, Wang Xianhuo, Xie Yao, Deng Hongxin, Chen Lijuan, Zhao Xia, Qian Zhiyong, Wei Yuquan
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China.
Int J Pharm. 2008 Jul 9;359(1-2):228-33. doi: 10.1016/j.ijpharm.2008.03.023. Epub 2008 Mar 25.
In this article, a novel local hydrophobic drug delivery system: nanoparticles in thermo-sensitive hydrogel, was demonstrated. First, honokiol, as a model hydrophobic drug, loaded poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) (PCEC) nanoparticles were prepared by emulsion solvent evaporation method, and then were incorporated into thermo-sensitive F127 hydrous matrix. The obtained injectable hydrophobic drug delivery system can act as a depot for sustained release of honokiol in situ. The lower critical solution temperature (LCST) of the composite matrix increases with increase in the mass of incorporated nanoparticles, or with decrease in the amount of residual organic solvent in the system. Honokiol release profile in vitro was studied, and the results showed that honokiol could be sustained released from the system. The described injectable drug delivery system might have great potential application for local delivery of hydrophobic drugs such as honokiol.
在本文中，展示了一种新型的局部疏水药物递送系统：热敏水凝胶中的纳米颗粒。首先，以厚朴酚作为模型疏水药物，通过乳液溶剂蒸发法制备负载聚（ε-己内酯）-聚（乙二醇）-聚（ε-己内酯）（PCEC）的纳米颗粒，然后将其掺入热敏性F127水合基质中。所获得的可注射疏水药物递送系统可作为原位持续释放厚朴酚的储库。复合基质的低临界溶液温度（LCST）随着掺入纳米颗粒质量的增加或系统中残留有机溶剂含量的减少而升高。研究了厚朴酚的体外释放曲线，结果表明厚朴酚可从该系统中持续释放。所描述的可注射药物递送系统对于局部递送如厚朴酚等疏水药物可能具有巨大的潜在应用价值。
