State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, PR China.
Drug Deliv. 2010 Apr;17(3):138-44. doi: 10.3109/10717541003604874.
This paper developed a new hydrophobic honokiol transdermal delivery system. First, Honokiol was loaded into Pluronic F127 micelles by direct dissolution method assisted by ultrasound. Then the obtained honokiol-loaded F127 micelles were incorporated into thermosensitive F127 hydrogel, which made the composite system bioadhesive. The particle size, drug loading, and encapsulation efficiency were determined. The sol-gel transitions of the copolymer, honokiol release profile in vitro, and the permeation studies in vitro were studied in detail. The lower critical solution temperature (LCST) of the composite system decreases with increase in the mass of honokiol in the system. Honokiol could be sustained released from the system in vitro. In in vitro permeation studies, honokiol could be absorbed per cutem. The described drug delivery system might have great potential application for transdermal delivery of hydrophobic drugs such as honokiol.
本文研制了一种新的厚朴酚透皮给药系统。首先，采用超声辅助直接溶解法将厚朴酚载入 Pluronic F127 胶束中。然后将所得的载厚朴酚 F127 胶束掺入温敏 F127 水凝胶中，使复合体系具有生物黏附性。测定了粒径、载药量和包封效率。详细研究了共聚物的溶胶-凝胶转变、体外厚朴酚释放曲线和体外渗透研究。复合体系的低临界溶液温度（LCST）随体系中厚朴酚质量的增加而降低。厚朴酚可以从体系中进行持续释放。在体外渗透研究中，厚朴酚可以经皮吸收。所述药物传递系统可能在透皮传递疏水性药物如厚朴酚方面具有很大的应用潜力。
