Ellidokuz Ender, Kaya Dayimi, Uslan Ihsan, Celik Ataç, Esen Ali Metin, Barutça Irfan
Department of Internal Medicine and Gastroenterology, School of Medicine, Celal Bayar University, Manisa, Turkey.
Clin Auton Res. 2008 Jun;18(3):145-9. doi: 10.1007/s10286-008-0469-9. Epub 2008 Apr 30.
Opioid receptors involved in regulating the motility of the gastrointestinal tract have been localized in both contractile and neuronal tissues. Trimebutine, a peripheral opioid receptor agonist, modulates gastrointestinal motor activity in both directions and also may act on cardiac tissue. This study investigated the effects of trimebutine in clinical doses on cardiac autonomic functions with heart rate variability. The effect of trimebutine on cardiac autonomic outflows was evaluated in 11 healthy subjects. Trimebutine (200 mg) or placebo was administered orally at random in a double-blind, cross-over manner. Continuous electrocardiography recordings were obtained before and after drug administration during three states: rest, controlled breathing, and a hand grip exercise. Heart rate variability analysis showed that there was no significant difference between subjects administered with placebo or trimebutine throughout rest, controlled breathing, or the hand grip exercise. We concluded that trimebutine, in clinical doses, has no significant effect on cardiac autonomic functions.
参与调节胃肠道蠕动的阿片受体已定位在收缩组织和神经组织中。曲美布汀是一种外周阿片受体激动剂，可双向调节胃肠运动活动，也可能作用于心脏组织。本研究通过心率变异性研究了临床剂量曲美布汀对心脏自主神经功能的影响。在11名健康受试者中评估了曲美布汀对心脏自主神经输出的影响。曲美布汀（200mg）或安慰剂以双盲、交叉方式随机口服给药。在休息、控制呼吸和握力运动三种状态下，给药前后均进行连续心电图记录。心率变异性分析表明，在整个休息、控制呼吸或握力运动过程中，服用安慰剂或曲美布汀的受试者之间没有显著差异。我们得出结论，临床剂量的曲美布汀对心脏自主神经功能没有显著影响。
