Chaussade S, Grandjouan S, Couturier D, Thierman-Duffaud D, Henry J F
Service d'Hépatogastroentérologie, Hôpital Cochin, Paris, France.
Eur J Clin Pharmacol. 1987;32(6):615-8. doi: 10.1007/BF02455998.
The effects of trimebutine, a drug used in the treatment of various gastrointestinal motility disorders, have been investigated fed and fasted healthy subjects. Duodenojejunal motility was recorded manometrically with a 4-lumen probe. Trimebutine 50 or 100 mg was injected i.v. 3 or 25 min after observing a spontaneous Phase 3 complex in the fasted state. Other experiments were done in the postprandial state and after intravenous naloxone 0.8 mg. In the fasted state, trimebutine 100 mg, injected 25 min after a spontaneous Phase 3 complex consistently induced a premature Phase 3 complex. The mean duration of the migrating motor complex cycle decreased from 86.4 +/- 10.8 min to 32.5 +/- 1.0 min. Trimebutine 50 mg injected 3 and 25 min after a spontaneous Phase 3 complex did not significantly modify the periodicity of the migrating motor complex. Trimebutine 100 mg initiated Phase 3-like activity in the post-prandial state. Previous intravenous administration of naloxone 0.8 mg (Narcan) suppressed the stimulatory action of TMB. Thus, trimebutine is able to modify the motility pattern in the small intestine of man, possibly by acting at opioid receptors.
已在进食和禁食的健康受试者中研究了用于治疗各种胃肠动力障碍的药物曲美布汀的作用。使用四腔探头通过测压法记录十二指肠空肠动力。在禁食状态下观察到自发的Ⅲ期复合波后3或25分钟静脉注射50或100毫克曲美布汀。其他实验在餐后状态和静脉注射0.8毫克纳洛酮后进行。在禁食状态下，在自发的Ⅲ期复合波后25分钟注射100毫克曲美布汀持续诱导提前出现的Ⅲ期复合波。移行性运动复合波周期的平均持续时间从86.4±10.8分钟降至32.5±1.0分钟。在自发的Ⅲ期复合波后3和25分钟注射50毫克曲美布汀并未显著改变移行性运动复合波的周期性。100毫克曲美布汀在餐后状态引发了类似Ⅲ期的活动。先前静脉注射0.8毫克纳洛酮（纳曲酮）可抑制曲美布汀的刺激作用。因此，曲美布汀可能通过作用于阿片受体来改变人体小肠的动力模式。
