[巴西圣保罗艾滋病患者和神经隐球菌病患者中新隐球菌荚膜多糖抗原的检测]

[Detection of capsular polysaccharide antigen of Cryptococcus neoformans in patients with AIDS and neurocryptococcosis in São Paulo, Brazil].

作者信息

Calvo B, Fischman O, Castelo Filho A, Reis Filho J, Del Bianco R, Barbosa R M, Zaror L

机构信息

Disc. Biologia Celular y Enfermedades Infecciosas y Parasitarias de Escola Paulista de Medicina, São Paulo, Brasil.

出版信息

Rev Inst Med Trop Sao Paulo. 1991 Nov-Dec;33(6):485-90.

PMID:1844979

Abstract

Capsular polysaccharide antigen (AgPC) of Cryptococcus neoformans was detected by latex agglutination technique (LA) in cerebrospinal fluid and serum of patients with AIDS during their first central nervous system manifestation of the disease. Direct mycological examination and culture were used as controls. Sensitivity was 100% by LA allowing an early specific treatment of cryptococcosis. Initial titres of AgPC in such patients can be > 1000000 and it appears that when such titres are present in the serum they are related to mortality during treatment. Surviving patients showed positivity of the direct mycological examination and AgPC of C. neoformans in cerebrospinal fluid and sera even after treatment and clinical recovery.

摘要

在艾滋病患者首次出现中枢神经系统疾病表现时，采用乳胶凝集技术（LA）检测其脑脊液和血清中的新型隐球菌荚膜多糖抗原（AgPC）。直接真菌学检查和培养作为对照。LA检测的敏感性为100%，可实现隐球菌病的早期特异性治疗。此类患者的AgPC初始滴度可>1000000，并且当血清中出现此类滴度时，似乎与治疗期间的死亡率相关。存活患者即使在治疗和临床康复后，脑脊液和血清中新型隐球菌的直接真菌学检查及AgPC仍呈阳性。