Barlas I Omer, Cetin Mesut, Erdal M Emin, Semiz Umit B, Basoglu Cengiz, Ay M Ertan, Herken Hasan, Uzun Ozcan
Department of Medical Biology and Genetics, Medical Faculty of Mersin University, Turkey.
Am J Med Genet B Neuropsychiatr Genet. 2009 Jan 5;150B(1):56-60. doi: 10.1002/ajmg.b.30770.
It is hypothesized that molecular components of dopaminergic system, especially the dopamine D3 receptor gene (DRD3), may play a crucial role in the pathophysiology of schizophrenia, because it is abundant in the limbic system of the brain and it binds antipsychotic drugs. Several groups attempted to find an association between a serine-to-glycine polymorphism of the DRD3 gene (Ser9Gly) and schizophrenia; however, the results were inconsistent. In this study, we aimed to investigate the relationship of the Serine/Glycine polymorphism of the DRD3 gene with therapeutic response to clozapine treatment between Turkish schizophrenia patients (N = 92) and healthy controls (N = 100). Genotype groups were comparable in BPRS, SAPS, SANS analysis of response to clozapine. Our results suggest that an association between the Ser/Gly polymorphism of DRD3 gene and response to clozapine in Turkish schizophrenia patients is unlikely to exist.
据推测，多巴胺能系统的分子成分，尤其是多巴胺D3受体基因（DRD3），可能在精神分裂症的病理生理学中起关键作用，因为它在大脑边缘系统中含量丰富且能与抗精神病药物结合。几个研究小组试图寻找DRD3基因的丝氨酸到甘氨酸多态性（Ser9Gly）与精神分裂症之间的关联；然而，结果并不一致。在本研究中，我们旨在调查土耳其精神分裂症患者（N = 92）和健康对照者（N = 100）中DRD3基因的丝氨酸/甘氨酸多态性与氯氮平治疗反应之间的关系。在对氯氮平反应的BPRS、SAPS、SANS分析中，基因型组具有可比性。我们的结果表明，在土耳其精神分裂症患者中，DRD3基因的Ser/Gly多态性与氯氮平反应之间不太可能存在关联。
