Chen C H, Liu M Y, Wei F C, Koong F J, Hwu H G, Hsiao K J
Division of Psychiatry, Cheng Hsin Rehabilitation and Medical Center, Taipei, Taiwan.
Am J Med Genet. 1997 Feb 21;74(1):40-3. doi: 10.1002/(sici)1096-8628(19970221)74:1<40::aid-ajmg9>3.0.co;2-z.
Dopamine D3 receptor (DRD3) was demonstrated to have important implications in schizophrenia, because it binds antipsychotic drugs and is abundant in the limbic system of the brain. Several groups attempted to find an association between a serine-to-glycine polymorphism at codon 9 of the DRD3 gene (Ser9Gly) and schizophrenia; however, the results were inconsistent. We conducted a case-control association study in Han Chinese schizophrenic patients from Taiwan, to examine the relationship of this serine-to-glycine polymorphism and schizophrenia. We noted no significant differences of genotype distribution, allele frequencies, or homozygosity proportion of this polymorphism between schizophrenic patients (N = 178) and controls (N = 100). When patients were divided according to sex, or presence or absence of family history, the differences were still not significant. Our study does not support the contention that the Ser9Gly polymorphism of the DRD3 gene plays a major role in schizophrenia.
多巴胺D3受体（DRD3）被证明在精神分裂症中具有重要意义，因为它能结合抗精神病药物，且在大脑边缘系统中含量丰富。多个研究小组试图寻找DRD3基因第9密码子丝氨酸到甘氨酸多态性（Ser9Gly）与精神分裂症之间的关联；然而，结果并不一致。我们对来自台湾的汉族精神分裂症患者进行了病例对照关联研究，以检验这种丝氨酸到甘氨酸多态性与精神分裂症的关系。我们发现，在精神分裂症患者（N = 178）和对照组（N = 100）之间，该多态性的基因型分布、等位基因频率或纯合子比例均无显著差异。当根据性别或有无家族史对患者进行分组时，差异仍然不显著。我们的研究不支持DRD3基因的Ser9Gly多态性在精神分裂症中起主要作用这一观点。
