Xin Yunchang, Jiang Jiang, Huo Kaifu, Tang Guoyi, Tian Xiubo, Chu Paul K
Department of Physics and Materials Science, City University of Hong Kong, Kowloon, China.
J Biomed Mater Res A. 2009 Jun;89(3):717-26. doi: 10.1002/jbm.a.32006.
The fast degradation rates in the physiological environment constitute the main limitation for the applications of surgical magnesium alloys as biodegradable hard-tissue implants. In this work, a stable and dense hydrogenated amorphous silicon coating (a-Si:H) with desirable bioactivity is deposited on AZ91 magnesium alloy using magnetron sputtering deposition. Raman spectroscopy and Fourier transform infrared spectroscopy reveal that the coating is mainly composed of hydrogenated amorphous silicon. The hardness of the coated alloy is enhanced significantly and the coating is quite hydrophilic as well. Potentiodynamic polarization results show that the corrosion resistance of the coated alloy is enhanced dramatically. In addition, the deterioration process of the coating in simulated body fluids is systematically investigated by open circuit potential evolution and electrochemical impedance spectroscopy. The cytocompatibility of the coated Mg is evaluated for the first time using hFOB1.19 cells and favorable biocompatibility is observed.
在生理环境中的快速降解速率是外科镁合金作为可生物降解硬组织植入物应用的主要限制因素。在这项工作中，采用磁控溅射沉积法在AZ91镁合金上沉积了具有理想生物活性的稳定致密氢化非晶硅涂层（a-Si:H）。拉曼光谱和傅里叶变换红外光谱表明，该涂层主要由氢化非晶硅组成。涂层合金的硬度显著提高，且涂层具有良好的亲水性。动电位极化结果表明，涂层合金的耐蚀性显著增强。此外，通过开路电位演变和电化学阻抗谱系统地研究了涂层在模拟体液中的劣化过程。首次使用hFOB1.19细胞评估了涂层镁的细胞相容性，并观察到良好的生物相容性。
