Heinz F, Holtzmann H, Essl A, Kundt M
Vopr Virusol. 2008 Mar-Apr;53(2):19-27.
Tick-borne encephalitis (TBE), the preventive measure against which is vaccination, is a disease caused by flavivirus (TBE virus). The infection is common in many European countries and in much of Central and Eastern Asia. Formaline-killed whole-virion high-purified vaccine inactivated is widely used for immunization of the population in Europe; however, the coverage of the population with vaccination greatly differs in the country where the natural foci of TBE are recorded. The exception is Austria where 88% of the population has been at least vaccinated against TBE and 58% has been regularly inoculated as evidenced by the officially recommended scheme. The present study has analyzed the efficacy of the above vaccine made in Austria in 2000 to 2006 in different age groups on the basis of documentary data on the cases of admissions for TBE among the unvaccinated and vaccinated and estimated the incidence of this disease in these groups, by taking into account the results of representative surveys. Our investigation has demonstrated that the efficiency of vaccination by the officially recommended scheme among the regularly inoculated persons is about 99% without statistically significant differences between the age groups. This result was observed after the first two vaccinations before completion of the basic course of vaccination, i.e. before the third vaccination; however, the efficiency of vaccination was substantially lower (about 95%) in the persons who had been irregularly inoculated, as shown by the records, i.e. they received the vaccine by the unofficial scheme. The findings confirm the high efficiency of vaccination of the population of Austria against TBE by the officially recommended scheme, which is shown in the prevention of about 2800 cases of TE.
蜱传脑炎（TBE）是一种由黄病毒（TBE病毒）引起的疾病，其预防措施是接种疫苗。这种感染在许多欧洲国家以及中亚和东亚的大部分地区都很常见。福尔马林灭活的全病毒高纯化疫苗在欧洲被广泛用于人群免疫；然而，在有TBE自然疫源地记录的国家，人群的疫苗接种覆盖率差异很大。奥地利是个例外，官方推荐方案显示，该国88%的人口至少接种过TBE疫苗，58%的人口进行过定期接种。本研究根据未接种疫苗者和接种疫苗者中TBE入院病例的文献数据，分析了2000年至2006年在奥地利生产的上述疫苗在不同年龄组中的效力，并结合代表性调查结果估算了这些组中该疾病的发病率。我们的调查表明，按照官方推荐方案定期接种疫苗的人群中，疫苗接种效率约为99%，各年龄组之间无统计学显著差异。这一结果是在完成基础疫苗接种疗程（即第三次接种）之前的前两次接种后观察到的；然而，记录显示，不定期接种疫苗的人群（即通过非官方方案接种疫苗的人群）的疫苗接种效率要低得多（约95%）。这些发现证实了按照官方推荐方案对奥地利人群进行TBE疫苗接种具有很高的效率，这体现在预防了约2800例TBE病例。
