Brodell Lindsey A, Beck Lisa A, Saini Sarbjit S
Department of Dermatology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Ann Allergy Asthma Immunol. 2008 Apr;100(4):291-7; quiz 297-9, 322. doi: 10.1016/S1081-1206(10)60588-1.
To review the literature on the pathogenesis of chronic urticaria (excluding physical urticaria).
PubMed was searched using the keywords urticaria and either chronic or autoimmune or pathogenesis for articles published from January 1972 to June 2007. All searches were limited to the English language. References from review articles on chronic urticaria were also considered for inclusion in this review.
The authors selected relevant and current sources for inclusion in this review.
No concise pathogenic mechanism has been identified for all cases of chronic urticaria, although evidence for a serologic mediator that may be autoimmune in nature has been identified in many cases. The activation of basophils and/or mast cells is a central feature in any theory proposed to explain this troubling disease.
Further research is needed to better define the mechanism or mechanism(s) responsible for the development of chronic urticaria. Such research will lead to more effective and possibly even curative treatments.
综述慢性荨麻疹（不包括物理性荨麻疹）发病机制的相关文献。
使用关键词“荨麻疹”以及“慢性”或“自身免疫性”或“发病机制”在PubMed上检索1972年1月至2007年6月发表的文章。所有检索仅限于英文文献。慢性荨麻疹综述文章的参考文献也被纳入本综述。
作者选择了相关且最新的资料纳入本综述。
虽然在许多病例中已发现一种可能具有自身免疫性质的血清学介质的证据，但尚未确定所有慢性荨麻疹病例的简明发病机制。嗜碱性粒细胞和/或肥大细胞的激活是任何解释这种令人困扰疾病的理论的核心特征。
需要进一步研究以更好地确定导致慢性荨麻疹发生的一种或多种机制。此类研究将带来更有效甚至可能治愈的治疗方法。
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