Spencer Kevin M
Department of Psychiatry, VA Boston Healthcare System, Brocton, Massachusetts, USA.
Clin EEG Neurosci. 2008 Apr;39(2):65-8. doi: 10.1177/155005940803900208.
Gamma oscillations may play an important role in the representation of information in the brain by synchronizing the firing of neurons in local and distributed neural circuits. The Bleulerian conceptualization of schizophrenia as "disintegration of thought and personality" suggests that neural mechanisms responsible for the integration of neural activity, such as gamma oscillations, might be particularly disrupted in this disorder. Here we review studies of gamma oscillations in healthy and schizophrenic individuals performing visual perception tasks. The findings suggest that schizophrenia is associated with a variety of abnormalities of visual gamma oscillations, which appear to be linked to core symptoms and cognitive deficits of schizophrenia. The relationships between these abnormalities and neural circuitry abnormalities in schizophrenia are discussed.
伽马振荡可能通过使局部和分布式神经回路中的神经元放电同步，在大脑信息表征中发挥重要作用。布鲁勒将精神分裂症概念化为“思维与人格解体”，这表明负责神经活动整合的神经机制，如伽马振荡，在这种疾病中可能会受到特别干扰。在此，我们回顾了健康个体和精神分裂症患者在执行视觉感知任务时的伽马振荡研究。研究结果表明，精神分裂症与视觉伽马振荡的多种异常有关，这些异常似乎与精神分裂症的核心症状和认知缺陷有关。本文还讨论了这些异常与精神分裂症神经回路异常之间的关系。
