Spencer Kevin M, Nestor Paul G, Niznikiewicz Margaret A, Salisbury Dean F, Shenton Martha E, McCarley Robert W
Department of Psychiatry, Harvard Medical School/Veterans Affairs Boston Healthcare System, Brockton, Massachusetts 02301, USA.
J Neurosci. 2003 Aug 13;23(19):7407-11. doi: 10.1523/JNEUROSCI.23-19-07407.2003.
Schizophrenia has been conceptualized as a failure of cognitive integration, and abnormalities in neural circuitry (particularly inhibitory interneurons) have been proposed as a basis for this disorder. We used measures of phase locking and phase coherence in the scalp-recorded electroencephalogram to examine the synchronization of neural circuits in schizophrenia. Compared with matched control subjects, schizophrenia patients demonstrated: (1) absence of the posterior component of the early visual gamma band response to Gestalt stimuli; (2) abnormalities in the topography, latency, and frequency of the anterior component of this response; (3) delayed onset of phase coherence changes; and (4) the pattern of anterior-posterior coherence increases in response to Gestalt stimuli found in controls was replaced by a pattern of interhemispheric coherence decreases in patients. These findings support the hypothesis that schizophrenia is associated with impaired neural circuitry demonstrated as a failure of gamma band synchronization, especially in the 40 Hz range.
精神分裂症已被概念化为认知整合失败，并且神经回路异常（特别是抑制性中间神经元）被认为是这种疾病的基础。我们使用头皮记录的脑电图中的锁相和相位相干测量方法来检查精神分裂症患者神经回路的同步性。与匹配的对照受试者相比，精神分裂症患者表现出：（1）对格式塔刺激的早期视觉伽马波段反应的后部成分缺失；（2）该反应前部成分的地形、潜伏期和频率异常；（3）相位相干变化的起始延迟；（4）对照组中发现的对格式塔刺激的前后相干增加模式被患者半球间相干减少模式所取代。这些发现支持了以下假设，即精神分裂症与神经回路受损有关，表现为伽马波段同步失败，尤其是在40赫兹范围内。
