Department of Psychology, University of A Coruña, La Coruña, Spain.
Psychophysiology. 2011 Sep;48(9):1217-26. doi: 10.1111/j.1469-8986.2011.01195.x. Epub 2011 Mar 29.
Deficits in processing contextual information are one of the main features of cognitive dysfunction in schizophrenia, but the neurophysiologic substrate underlying this dysfunction is poorly understood. We used ERPs to investigate local contextual processing in schizophrenic patients. Local context was defined as the occurrence of a short predictive series of stimuli occurring before delivery of a target event. Response times of predicted targets were faster in controls compared to patients. Schizophrenia patients failed to generate the P3b latency shift between predicted and random targets that was observed in controls and demonstrated a prominent reduction of the peak of an early latency context dependent positivity. The current study provides evidence of contextual processing deficits in schizophrenia patients by demonstrating alteration in the behavioral and neural correlates of local contextual processing.
处理上下文信息的缺陷是精神分裂症认知功能障碍的主要特征之一，但这种功能障碍的神经生理基础还了解甚少。我们使用事件相关电位（ERP）来研究精神分裂症患者的局部上下文处理。局部上下文定义为在目标事件发生之前发生的短预测刺激序列的出现。与患者相比，对照组的预测目标的反应时间更快。精神分裂症患者未能在预测和随机目标之间产生 P3b 潜伏期变化，而对照组则观察到这种变化，并表现出早期潜伏期上下文相关正性波峰值的明显降低。本研究通过证明局部上下文处理的行为和神经相关性的改变，为精神分裂症患者的上下文处理缺陷提供了证据。
