病态赌徒血小板5-羟色胺转运体密度降低。
Decreased density of the platelet serotonin transporter in pathological gamblers.
作者信息
Marazziti Donatella, Golia Francesca, Picchetti Michela, Pioli Ellena, Mannari Patrizia, Lenzi Francesco, Conversano Ciro, Carmassi Claudia, Catena Dell'Osso Mario, Consoli Giorgio, Baroni Stefano, Giannaccini Gino, Zanda Giuseppe, Dell'Osso Liliana
机构信息
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa, Italy.
出版信息
Neuropsychobiology. 2008;57(1-2):38-43. doi: 10.1159/000129665. Epub 2008 May 2.
BACKGROUND/AIMS: The aim of this study was to investigate the serotonin transporter (SERT), by means of the 3H-paroxetine ([3H]-Par) binding to platelet membranes, in patients affected by pathological gambling (PG), as compared with a similar group of healthy control subjects.
METHODS
Seventeen PG patients were selected amongst those who were drug-free and at the first psychiatric interview in a Department of Addiction. The diagnosis was assessed according to DSM-IV criteria and PG severity was measured by means of the South Oaks Gambling Screen. The platelet [3H]-Par binding was carried out according to a standardized method. The binding parameters, the maximum binding capacity (B(max)) and the dissociation constant (K(d)), were obtained by means of the Scatchard analysis.
RESULTS
The B(max) values of PG patients were significantly lower than that of healthy subjects, while the K(d) values were not different in the two groups. No significant effect of age, sex or psychiatric comorbidity on B(max) or K(d) was observed; there were also no correlations between clinical and biological variables.
CONCLUSIONS
PG patients showed a dysfunction at the level of the platelet SERT that would suggest the involvement of the 5-HT system in this condition.
背景/目的：本研究旨在通过3H-帕罗西汀（[3H]-Par）与血小板膜结合的方法，调查病态赌博（PG）患者与相似健康对照组受试者相比的5-羟色胺转运体（SERT）情况。
方法
从成瘾科首次接受精神科访谈且未使用药物的患者中选取17例PG患者。根据《精神疾病诊断与统计手册》第四版（DSM-IV）标准进行诊断，并用南橡树赌博筛查量表测量PG严重程度。血小板[3H]-Par结合实验按照标准化方法进行。通过Scatchard分析获得结合参数，即最大结合容量（B(max)）和解离常数（K(d)）。
结果
PG患者的B(max)值显著低于健康受试者，而两组的K(d)值无差异。未观察到年龄、性别或精神共病对B(max)或K(d)有显著影响；临床和生物学变量之间也无相关性。
结论
PG患者血小板SERT水平存在功能障碍，提示5-羟色胺（5-HT）系统参与了这种情况。
Zotero 插件