Conversano Ciro, Di Giuseppe Mariagrazia, Miccoli Mario, Ciacchini Rebecca, Di Silvestre Annarita, Lo Sterzo Rosa, Gemignani Angelo, Orrù Graziella
Department of Surgical, Medical and Molecular Pathology, Critical and Care Medicine, University of Pisa, Italy.
Department of Clinical and Experimental Medicine, University of Pisa, Italy.
Clin Neuropsychiatry. 2020 Aug;17(4):217-224. doi: 10.36131/cnfioritieditore20200403.
Psychological distress is common in cancer patients during the diagnostic phase. Research demonstrated that anxiety, depression and defense mechanisms may influence physical and psychological well-being in patients with malignant tumors. The present retrospective study investigated the associations between clinical and psychological characteristics of cancer patients waiting for the diagnosis, focusing on metastatic cancer (MC) and breast cancer (BC).
Patients with a new diagnosis of cancer referring to a Clinical Oncology Unit in Central Italy were interviewed during the 2017 for psychological assessment. Double-blind information about anxiety, depression, sleep disorders, defense style, and cancer diagnosis were available for the 567 patients included in this study. T-test, chi-squared and regression analyses were performed to detect associations between psychological variables and the presence of metastasis (MC) in the whole sample and in the subgroup of breast cancer (BC) patients.
Female gender and younger age were associated with anxiety, depression, and maladaptive defense style. A significant positive relationship was found between presence of metastasis and symptoms of anxiety. Depression resulted significantly more frequent in BC, while there was a trend close to statistical significance in MC. Immature defense style was widely used by BC women, with a score close to statistical significance.
This retrospective study provided empirical evidence of the relationship between psychological functioning and clinical characteristics of cancer. In line with previous research, our findings confirmed the peculiar psychological functioning of BC patients. Further investigations are needed to understand how the diagnosis of cancer may influence the individual psychological functioning and vice versa.
在癌症诊断阶段,心理困扰在癌症患者中很常见。研究表明,焦虑、抑郁和防御机制可能会影响恶性肿瘤患者的身心健康。本回顾性研究调查了等待诊断的癌症患者的临床特征与心理特征之间的关联,重点关注转移性癌症(MC)和乳腺癌(BC)。
2017年期间,对转诊至意大利中部一家临床肿瘤科室的新诊断癌症患者进行了心理评估访谈。本研究纳入的567例患者可获得关于焦虑、抑郁、睡眠障碍、防御方式和癌症诊断的双盲信息。进行了t检验、卡方检验和回归分析,以检测心理变量与整个样本以及乳腺癌(BC)患者亚组中转移(MC)的存在之间的关联。
女性和较年轻的年龄与焦虑、抑郁和适应不良的防御方式相关。转移的存在与焦虑症状之间存在显著的正相关关系。抑郁在乳腺癌患者中明显更常见,而在转移性癌症患者中存在接近统计学显著性的趋势。未成熟防御方式在乳腺癌女性中广泛使用,得分接近统计学显著性。
这项回顾性研究为癌症患者心理功能与临床特征之间的关系提供了实证证据。与先前的研究一致,我们的研究结果证实了乳腺癌患者独特的心功能。需要进一步研究以了解癌症诊断如何影响个体心理功能,反之亦然。