Morena Marion, Gausson Valérie, Mothu Nadya, Bouchet Jean-Louis, Chanas Monique, Grandvuillemin Mireille, Robert Alain, Vela Carlos, Canaud Bernard, Cristol Jean-Paul, Olmer Michel
Laboratoire de Biochimie, Centre Hospitalier Universitaire, Université Montpellier I, Montpellier, France.
Blood Purif. 2008;26(3):300-10. doi: 10.1159/000128991. Epub 2008 May 2.
BACKGROUND/AIMS: This study aimed at evaluating oxidative stress (OS) markers (i) in a cross-sectional study of hemodialysis (HD) patients to investigate potential regional effects of these markers and (ii) in a prospective crossover study to evaluate vitamin E-coated membrane (VE) effects.
At baseline, OS parameters including low-density lipoprotein (LDL) oxidizability were measured in HD patients from five dialysis facilities. Patients were then randomly assigned to two treatment groups: group I patients (n = 33) switching to VE, and group II patients (n = 29) still using reference polysulfone (PS) membrane. After 3 months, patients were switched from VE to PS and vice versa for 6 months. The same OS parameters were measured after each period.
At baseline, the cross-sectional analysis of LDL oxidizability showed a regional effect. By contrast, the crossover study did not show beneficial effects of VE on this parameter.
Regional variations of LDL oxidizability in HD patients exist and may explain discrepancies in interventional therapy on OS.
背景/目的：本研究旨在评估氧化应激（OS）标志物，（i）在一项血液透析（HD）患者的横断面研究中，调查这些标志物潜在的区域效应；（ii）在一项前瞻性交叉研究中，评估维生素E涂层膜（VE）的效果。
在基线时，对来自五个透析机构的HD患者测量包括低密度脂蛋白（LDL）氧化能力在内的OS参数。然后将患者随机分为两个治疗组：第一组患者（n = 33）改用VE，第二组患者（n = 29）仍使用对照聚砜（PS）膜。3个月后，患者从VE改为PS，反之亦然，持续6个月。在每个阶段后测量相同的OS参数。
在基线时，LDL氧化能力的横断面分析显示出区域效应。相比之下，交叉研究未显示VE对该参数有有益影响。
HD患者中存在LDL氧化能力的区域差异，这可能解释了OS介入治疗中的差异。
