[糜烂性反流性食管炎中胃泌素、胃蛋白酶原与幽门螺杆菌的关系]

[The relationship of gastrin, pepsinogen, and Helicobacter pylori in erosive reflux esophagitis].

作者信息

Kwon Jung Hyun, Chung In-Sik, Son Hye Suk, Park Jae Myung, Cho Yu Kyung, Lee In Seok, Kim Sang Woo, Choi Myung Gyu

机构信息

Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

出版信息

Korean J Gastroenterol. 2008 Mar;51(3):159-66.

PMID:18451689

Abstract

BACKGROUND/AIMS: Helicobacter pylori (H. pylori) infection is known as a major cause of atrophic gastritis and is associated with serum gastrin, pepsinogen, and gastric acid secretion. There is still a controversial association between gastroesophageal reflux disease and H. pylori infection. This study was designed to investigate the relationship among serum gastrin, pepsinogen, and H. pylori infection in the erosive reflux esophagitis (ERD) patients.

METHODS

Patients who were diagnosed as ERD by one gastroenterologist at the Kangnam St. Mary's hospital were prospectively enrolled. The persons without ERD in the control group were matched for age and sex. We examined the gastrin, pepsinogen I (PG I), PG II, PG I/II ratio, and H. pylori infection.

RESULTS

Forty five patients were enrolled in ERD group and 66 persons in control group. The H. pylori infection rate in ERD group was lower than that in the control group (11.1% vs. 43.9%, p<0.001). PG I/II ratio in ERD group was higher than that in the control group (7.0+/-3.1 vs. 5.3+/-2.6, p=0.003). The PG II (p=0.016) and gastrin (p=0.029) in ERD group were lower than those in the control group. BMI in ERD group was higher than that in the control group (24.5 vs. 23.1 kg/m2, p=0.013).

CONCLUSIONS

The H. pylori infection rate in ERD group was lower and PG I/II ratio was higher than that in the control group. Reflux esophagitis is thought to be reversely associated with the atrophy of gastric mucosa.

摘要

背景/目的：幽门螺杆菌（H. pylori）感染是萎缩性胃炎的主要病因，且与血清胃泌素、胃蛋白酶原及胃酸分泌有关。胃食管反流病与幽门螺杆菌感染之间的关联仍存在争议。本研究旨在探讨糜烂性反流性食管炎（ERD）患者血清胃泌素、胃蛋白酶原与幽门螺杆菌感染之间的关系。

方法

前瞻性纳入江南圣母医院一名胃肠病学家诊断为ERD的患者。对照组中无ERD的人员按年龄和性别进行匹配。我们检测了胃泌素、胃蛋白酶原I（PG I）、PG II、PG I/II比值及幽门螺杆菌感染情况。

结果

ERD组纳入45例患者，对照组纳入66例。ERD组幽门螺杆菌感染率低于对照组（11.1%对43.9%，p<0.001）。ERD组PG I/II比值高于对照组（7.0±3.1对5.3±2.6，p=0.003）。ERD组PG II（p=0.016）和胃泌素（p=0.029）低于对照组。ERD组体重指数高于对照组（24.5对23.1 kg/m2，p=0.013）。