Polat Fatin R, Polat Sabriye
Department of Surgery, New City State Hospital, Sakarya, Turkey.
JSLS. 2012 Apr-Jun;16(2):260-3. doi: 10.4293/108680812x13427982376860.
Helicobacter pylori infection represents one of the most common and medically prominent infections worldwide. Gastroesophageal reflux disease (GERD) has a multifactorial etiology. The nature of the relationship between Helicobacter pylori infection (HP) and reflux esophagitis is still not clear. This study is designed to find the influence of HP on GERD.
The study was conducted retrospectively at Sakarya Newcity Hospital between January 2006 and January 2009. Data were collected on patient's age, sex, weight, the grade of GERD and the severity of HP.
There were 1,307 women and 1,135 men in this review with a mean age of 39,54 (range, 17 to 70) years. Helicobacter pylori positive (1 to 3 severity) was frequently seen in patients with GERD. A statistically significant relationship was found between HP positivity and the grade of GERD. The Helicobacter pylori infection (1 to 3 severity) was found in 1,437 (82.5%) of patients with GERD in our series.
Controversy still exists about the association between GERD and HP infection. Based on our findings, significant evidence suggests the potential role of HP infection in the development of GERD. Also, the current data provide sufficient evidence to define the relationship between GERD and HP infection.
幽门螺杆菌感染是全球最常见且在医学上较为突出的感染之一。胃食管反流病（GERD）病因多方面。幽门螺杆菌感染（HP）与反流性食管炎之间关系的本质仍不明确。本研究旨在探寻HP对GERD的影响。
本研究于2006年1月至2009年1月在萨卡里亚新城医院进行回顾性研究。收集了患者的年龄、性别、体重、GERD分级以及HP严重程度的数据。
本综述中有1307名女性和1135名男性，平均年龄为39.54岁（范围17至70岁）。GERD患者中幽门螺杆菌阳性（严重程度为1至3级）较为常见。HP阳性与GERD分级之间存在统计学显著关系。在我们的系列研究中，1437名（82.5%）GERD患者存在幽门螺杆菌感染（严重程度为1至3级）。
GERD与HP感染之间的关联仍存在争议。基于我们的研究结果，有重要证据表明HP感染在GERD发生发展中可能发挥作用。此外，当前数据为明确GERD与HP感染之间的关系提供了充分证据。
