Choi Dae Han, Kim Hae Kyung, Park Tae Il, John Byung Min, Kang Sung Hwan, Lee Yoon Serk, Kim Tae Hyun, Lee Uh Joo, Lee Tae Seung, Yoon Gwi Ok
Department of Internal Medicine, Kwang Myung SungAe Hospital, Gwangmyeong, Korea.
Korean J Gastroenterol. 2008 Mar;51(3):190-3.
Overlap of autoimmune hepatitis and systemic lupus erythematosus (SLE) is a comparatively rare condition. Although both autoimmune hepatitis and SLE can share common autoimmune features such as polyarthralgia, hypergammaglobulinemia and positive ANA, it has been considered as two different entities. We report a case of anti-LKM1 positive autoimmune hepatitis who developed SLE two years later. The presence of interface hepatitis with lymphoplasma cell infiltrates and rosette formation points to the autoimmune hepatitis rather than SLE hepatitis. Autoimmune hepatitis is infrequently accompanied by SLE, therefore, it could be recommended to investigate for SLE in patients with autoimmune hepatitis.
自身免疫性肝炎与系统性红斑狼疮(SLE)重叠是一种相对罕见的情况。尽管自身免疫性肝炎和SLE都可具有多关节痛、高球蛋白血症和抗核抗体阳性等共同的自身免疫特征,但它们一直被视为两种不同的疾病实体。我们报告一例抗LKM1阳性的自身免疫性肝炎患者,该患者两年后发生了SLE。伴有淋巴细胞浆细胞浸润和玫瑰花结形成的界面性肝炎提示为自身免疫性肝炎而非SLE肝炎。自身免疫性肝炎很少伴有SLE,因此,建议对自身免疫性肝炎患者进行SLE检查。