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Rapid clearance of methylprednisolone after intratympanic application in humans. Comment on: Bird PA, Begg EJ, Zhang M, et al. Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph. Otol Neurotol 2007;28:1124-30.

作者信息

Plontke Stefan K, Mikulec Anthony A, Salt Alec N

出版信息

Otol Neurotol. 2008 Aug;29(5):732-3; author reply 733. doi: 10.1097/MAO.0b013e318173fcea.

DOI:10.1097/MAO.0b013e318173fcea
PMID:18451748
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2596997/
Abstract
摘要

相似文献

1
Rapid clearance of methylprednisolone after intratympanic application in humans. Comment on: Bird PA, Begg EJ, Zhang M, et al. Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph. Otol Neurotol 2007;28:1124-30.在人体中鼓室内应用甲泼尼龙后的快速清除。对以下文献的评论：Bird PA, Begg EJ, Zhang M等。甲泼尼龙鼓室内给药与静脉给药至耳蜗外淋巴。《耳科及神经耳科学》2007年；28卷：1124 - 1130页
Otol Neurotol. 2008 Aug;29(5):732-3; author reply 733. doi: 10.1097/MAO.0b013e318173fcea.
2
Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph.鼓室内注射与静脉注射甲基强的松龙至耳蜗外淋巴液的比较。
Otol Neurotol. 2007 Dec;28(8):1124-30. doi: 10.1097/MAO.0b013e31815aee21.
3
Are intratympanic injections of N-acetylcysteine and methylprednisolone protective against Cisplatin-induced ototoxicity?鼓室内注射 N-乙酰半胱氨酸和甲泼尼龙是否能预防顺铂诱导的耳毒性？
J Otolaryngol Head Neck Surg. 2010 Jun;39(3):236-43.
4
Entry of substances into perilymph through the bone of the otic capsule after intratympanic applications in guinea pigs: implications for local drug delivery in humans.豚鼠鼓室内给药后物质通过耳囊骨进入外淋巴：对人类局部药物递送的意义
Otol Neurotol. 2009 Feb;30(2):131-8. doi: 10.1097/mao.0b013e318191bff8.
5
Intratympanic versus intravenous delivery of dexamethasone and dexamethasone sodium phosphate to cochlear perilymph.鼓室内与静脉内给予地塞米松和地塞米松磷酸钠至耳蜗外淋巴液。
Otol Neurotol. 2011 Aug;32(6):933-6. doi: 10.1097/MAO.0b013e3182255933.
6
Re: Sudden hearing loss.关于：突发性听力损失。
Clin Otolaryngol. 2008 Apr;33(2):155-6; author reply 156-7. doi: 10.1111/j.1749-4486.2008.01646.x.
7
Systemic, intratympanic and combined administration of steroids for sudden hearing loss. A prospective randomized multicenter trial.全身、鼓室内及联合应用类固醇治疗突发性听力损失。一项前瞻性随机多中心试验。
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8
The pharmacokinetic profiles of dexamethasone and methylprednisolone concentration in perilymph and plasma following systemic and local administration.全身和局部给药后地塞米松和甲泼尼龙在外淋巴液和血浆中的药代动力学特征。
Acta Otolaryngol. 2008 May;128(5):496-504. doi: 10.1080/00016480701558906.
9
Modified intratympanic treatment for idiopathic sudden sensorineural hearing loss.改良鼓室内治疗特发性突发性聋。
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10
Comparison of contrast effect on the cochlear perilymph after intratympanic and intravenous gadolinium injection.鼓室内和静脉内钆注射后对耳蜗外淋巴对比效果的比较。
AJNR Am J Neuroradiol. 2012 Apr;33(4):773-8. doi: 10.3174/ajnr.A2821. Epub 2011 Dec 15.

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Drug Deliv. 2023 Dec;30(1):2242003. doi: 10.1080/10717544.2023.2242003.
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Efficiency of a dexamethasone nanosuspension as an intratympanic injection for acute hearing loss.地塞米松纳米混悬剂作为鼓室内注射治疗急性听力损失的疗效。
Drug Deliv. 2022 Dec;29(1):149-160. doi: 10.1080/10717544.2021.2021320.
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Int J Pharm X. 2019 May 21;1:100015. doi: 10.1016/j.ijpx.2019.100015. eCollection 2019 Dec.
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Sci Transl Med. 2019 Mar 6;11(482). doi: 10.1126/scitranslmed.aao0935.
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Hearing Changes After Intratympanic Steroids for Secondary (Salvage) Therapy of Sudden Hearing Loss: A Meta-Analysis Using Mathematical Simulations of Drug Delivery Protocols.鼓室内类固醇给药方案的数学模拟在挽救性治疗突发性聋中的应用：对听力改变的Meta 分析。
Otol Neurotol. 2018 Aug;39(7):803-815. doi: 10.1097/MAO.0000000000001872.
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Pharmacokinetic principles in the inner ear: Influence of drug properties on intratympanic applications.内耳的药代动力学原理：药物性质对鼓室内应用的影响。
Hear Res. 2018 Oct;368:28-40. doi: 10.1016/j.heares.2018.03.002. Epub 2018 Mar 11.
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Intratympanic glucocorticosteroid therapy for idiopathic sudden hearing loss: Meta-analysis of randomized controlled trials.鼓室内糖皮质激素治疗特发性突发性感音神经性听力损失：随机对照试验的荟萃分析
Medicine (Baltimore). 2017 Dec;96(50):e8955. doi: 10.1097/MD.0000000000008955.
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Innovative pharmaceutical approaches for the management of inner ear disorders.用于内耳疾病管理的创新药物方法。
Drug Deliv Transl Res. 2018 Apr;8(2):436-449. doi: 10.1007/s13346-017-0384-5.
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Reduction of permanent hearing loss by local glucocorticoid application : Guinea pigs with acute acoustic trauma.局部应用糖皮质激素减少永久性听力损失：急性声损伤豚鼠
HNO. 2017 Jan;65(Suppl 1):59-67. doi: 10.1007/s00106-016-0266-z.

本文引用的文献

1
Dexamethasone concentration gradients along scala tympani after application to the round window membrane.将地塞米松应用于圆窗膜后，沿鼓阶的地塞米松浓度梯度。
Otol Neurotol. 2008 Apr;29(3):401-6. doi: 10.1097/MAO.0b013e318161aaae.
2
Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph.鼓室内注射与静脉注射甲基强的松龙至耳蜗外淋巴液的比较。
Otol Neurotol. 2007 Dec;28(8):1124-30. doi: 10.1097/MAO.0b013e31815aee21.
3
Cochlear microdialysis for quantification of dexamethasone and fluorescein entry into scala tympani during round window administration.圆窗给药期间，采用耳蜗微透析法对鼓阶内的地塞米松和荧光素进入量进行定量分析。
Hear Res. 2006 Feb;212(1-2):236-44. doi: 10.1016/j.heares.2005.12.001. Epub 2006 Jan 25.
4
Quantitative interpretation of corticosteroid pharmacokinetics in inner fluids using computer simulations.使用计算机模拟对内部液体中皮质类固醇的药代动力学进行定量解释。
Hear Res. 2003 Aug;182(1-2):34-42. doi: 10.1016/s0378-5955(03)00138-2.
5
[Permeability of the round window membrane for prednisolone-21-hydrogen succinate. Prednisolone content of the perilymph after local administration vs. systemic injection].[琥珀酸氢化泼尼松对圆窗膜的通透性。局部给药与全身注射后外淋巴液中泼尼松的含量]
HNO. 2001 Jul;49(7):538-42. doi: 10.1007/s001060170078.