五选择连续反应时任务在大鼠视觉注意过程和冲动控制评估中的应用。
The application of the 5-choice serial reaction time task for the assessment of visual attentional processes and impulse control in rats.
作者信息
Bari Andrea, Dalley Jeffrey W, Robbins Trevor W
机构信息
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK.
出版信息
Nat Protoc. 2008;3(5):759-67. doi: 10.1038/nprot.2008.41.
One popular way of measuring visual attentional processes in the rat is using 5-choice serial reaction time task (5-CSRTT). This paradigm requires subjects to detect brief flashes of light presented in a pseudorandom order in one of five spatial locations over a large number of trials. For this task, the animals are trained for approximately 30-40 daily sessions during which they gradually learn to respond in the appropriate aperture within a certain amount of time. If they fail to respond, respond in the wrong hole or at an inappropriate time, a short period of darkness (time-out) is presented as punishment and no reward is delivered. The 5-CSRTT provides the possibility to test the effects of various neural, pharmacological and behavioral manipulations on discrete and somewhat independent measures of behavioral control, including accuracy of discrimination, impulsivity, perseverative responses and response latencies.
在大鼠中测量视觉注意力过程的一种常用方法是使用5选串行反应时任务（5-CSRTT）。这种范式要求受试者在大量试验中检测在五个空间位置之一以伪随机顺序呈现的短暂闪光。对于这项任务，动物每天接受大约30-40次训练，在此期间它们逐渐学会在一定时间内在适当的光圈内做出反应。如果它们没有做出反应、在错误的孔中做出反应或在不适当的时间做出反应，会出现短时间的黑暗（超时）作为惩罚，并且不给奖励。5-CSRTT提供了测试各种神经、药理学和行为操作对行为控制的离散且 somewhat independent 测量指标（包括辨别准确性、冲动性、持续性反应和反应潜伏期）的影响的可能性。 （注：原文中“somewhat independent”表述不太准确，可能是“somewhat interdependent”之类的词，但按照要求未修改。）
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