Cordier A C, Scolari L, Vaerman J P, Dutrieux-Fauchet M C, Dutrieux C, Haumont S
Scand J Haematol. 1976 Aug;17(2):143-52. doi: 10.1111/j.1600-0609.1976.tb01168.x.
A case of apparently benign plasma cell proliferation is described. Needle-like paracrystalline inclusions were observed in numerous plasma cells outside the cisternae of the rough endoplasmic reticulum. They had a dense protein core surrounded by a layer of carbohydrate. They were found only in plasma cells secreting IgA-kappa immunoglobulin, but did not react with labelled specific antisera. A small amount of paraprotein IgA-kappa was found in the serum but no Bence-Jones protein could be detected in the urine. These observations suggest that these plasma cells synthesize normal IgA immunoglobulin and accumulate abnormal protein in the form of paracrystalline inclusions.
