Ricci A, Monahan R A, Paradise C, Robinson S, Dvorak A M
Arch Pathol Lab Med. 1982 Sep;106(9):452-7.
The bone marrow from a patient with Waldenström's macroglobulinemia was studied, and histologic, immunopathologic, and ultrastructural features correlated. The infiltrating plasmacytoid lymphocytes contained PAS-negative cytoplasmic inclusions, which were shown to contain a specific immunoglobulin that matched the patients's circulating paraprotein. Electron microscopic studies revealed abundant dense fibrillar and globular material within dilated cisternae of rough endoplasmic reticulum. This material was morphologically similar to, but quantitatively different from, an endoplasmic reticulum-associated structure previously described in several patients with chronic lymphocytic leukemia. The differences between these fibrillar inclusions and Russell bodies are stressed.
对一名华氏巨球蛋白血症患者的骨髓进行了研究，并将组织学、免疫病理学和超微结构特征进行了关联分析。浸润的浆细胞样淋巴细胞含有PAS阴性的胞质内含物，结果显示这些内含物含有一种与患者循环副蛋白相匹配的特异性免疫球蛋白。电子显微镜研究显示，粗面内质网扩张的池内有大量致密的纤维状和球状物质。这种物质在形态上与先前在几名慢性淋巴细胞白血病患者中描述的内质网相关结构相似，但在数量上有所不同。强调了这些纤维状内含物与拉塞尔小体之间的差异。
