Teske Jesse A, Deiters Alexander
North Carolina State University, Department of Chemistry, Raleigh, North Carolina 27695-8204, USA.
Org Lett. 2008 Jun 5;10(11):2195-8. doi: 10.1021/ol800589e. Epub 2008 May 2.
Three members of the cannabinoid class, cannabinol, cannabinol methyl ether, and cannabinodiol, were synthesized using a microwave-mediated [2 + 2 + 2] cyclotrimerization reaction as the key step. This approach provides a high level of synthetic flexibility allowing for the facile synthesis of cannabinoid analogues.
