Namazi M R, Jowkar F
Dermatology Department, Wake-Forest University Baptist Medical Center, Wisnston-Salem, NC, USA.
J Clin Pharm Ther. 2008 Jun;33(3):215-7. doi: 10.1111/j.1365-2710.2008.00907.x.
Proton pump inhibitors (PPI) are a group of anti-ulcer agents. PPI have selective anti-cancer effects via apoptosis of tumour, sensitization of cancer cell to chemotherapy and radiotherapy. Also PPI have anti-malarial and anti-leishmanial activity. Rising of endosomal (P)H inhibits the presentation of antigens that enter cell through endocytosis. PPI can affect transmigration of leucocytes from vessels to inflammatory sites and also can mitigate neutrophile adherence to endothelial cell. PPI increase the intralysosomal (P)H and decrease the expression of intracellular adhesion molecules. Therefore PPI can exert immunomodulation in immunological diseases through hampering antigen processing, antigen presentation, and leucocytes transmigration.
质子泵抑制剂（PPI）是一类抗溃疡药物。PPI通过肿瘤细胞凋亡、使癌细胞对化疗和放疗敏感而具有选择性抗癌作用。此外，PPI还具有抗疟疾和抗利什曼原虫活性。内体pH值升高会抑制通过内吞作用进入细胞的抗原的呈递。PPI可影响白细胞从血管向炎症部位的迁移，还可减轻中性粒细胞与内皮细胞的黏附。PPI可提高溶酶体内pH值并降低细胞内黏附分子的表达。因此，PPI可通过阻碍抗原加工、抗原呈递和白细胞迁移在免疫性疾病中发挥免疫调节作用。
