Chabardès S, Minotti L, Chassagnon S, Piallat B, Torres N, Seigneuret E, Vercueil L, Carron R, Hirsch E, Kahane P, Benabid A L
Clinique universitaire de neurochirurgie, pôle tête, cou et chirurgie réparatrice, hôpital Michallon,CHU de Grenoble, B.P. 217, 38043 Grenoble cedex, France.
Neurochirurgie. 2008 May;54(3):436-40. doi: 10.1016/j.neuchi.2008.02.039. Epub 2008 May 2.
The surgical treatment of intractable epilepsies involving eloquent areas of the cortex is still challenging. Deep-brain stimulation could be an alternative to resective surgery because it can modulate the remote control systems of epilepsy, such as the thalamus and basal ganglia. The surgical experience acquired in the field of movement disorder surgery and the low morbidity of this technic could allow one to apply DBS to intractable epilepsies, such as generalized, motor and bitemporal epilepsies. Here we discuss the main experimental and clinical data reported so far in the literature and taken from our own experience.
涉及大脑皮层功能区的难治性癫痫的外科治疗仍然具有挑战性。脑深部电刺激可能是切除性手术的一种替代方法，因为它可以调节癫痫的远程控制系统，如丘脑和基底神经节。在运动障碍手术领域积累的手术经验以及该技术的低发病率使得人们可以将脑深部电刺激应用于难治性癫痫，如全身性、运动性和双侧颞叶癫痫。在此，我们讨论迄今为止文献中报道的以及来自我们自身经验的主要实验和临床数据。
