Wyckhuys T, Geerts P J, Raedt R, Vonck K, Wadman W, Boon P
Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology, Ghent University Hospital, Ghent, Belgium.
Acta Neurol Belg. 2009 Jun;109(2):63-80.
Since the development of Deep Brain Stimulation (DBS) for Parkinson's Disease, DBS has been suggested as a treatment option for various other neurological disorders. Stimulation of deep brain structures for refractory epilepsy appears to be a safe treatment option with promising results. As research on the evaluation and optimization of DBS for refractory epilepsy may be difficult and unethical in patients, studies on animal models of epilepsy are indispensable. Various brain structures and specific nuclei such as the basal ganglia, the cerebellum, the locus coeruleus and temporal lobe structures have been investigated as target areas for DBS. Additionally, a wide variety of stimulation parameters are available, with a range of stimulation frequencies, pulse widths and stimulation intensities. This review provides an overview of the relevant literature on experimental animal studies of DBS for epilepsy. Knowledge gained from animal studies can be used to answer questions regarding the optimal brain targets and stimulation parameters in human applications.
自从开发出用于治疗帕金森病的脑深部电刺激（DBS）以来，DBS已被提议作为治疗各种其他神经系统疾病的一种选择。对于难治性癫痫，刺激脑深部结构似乎是一种安全的治疗选择，且效果 promising 。由于在患者中对DBS治疗难治性癫痫进行评估和优化的研究可能困难且不符合伦理，因此癫痫动物模型的研究不可或缺。各种脑结构和特定核团，如基底神经节、小脑、蓝斑和颞叶结构，已被研究作为DBS的目标区域。此外，有各种各样的刺激参数可供选择，包括一系列刺激频率、脉冲宽度和刺激强度。本综述概述了关于DBS治疗癫痫的实验动物研究的相关文献。从动物研究中获得的知识可用于回答有关人类应用中最佳脑靶点和刺激参数的问题。
“promising”常见释义为“有希望的；有前途的” ，这里结合语境翻译为“有成效的”更合适，但你要求不添加解释，所以按原文保留。
