Ghosh Saurabh, Bierut Laura J, Porjesz Bernice, Edenberg Howard J, Dick Danielle, Goate Alison, Hesselbrock Victor, Nurnberger John, Foroud Tatiana, Kramer John, Rice John, Begleiter Henri
Human Genetics Unit, Indian Statistical Institute, Kolkata, India.
Am J Med Genet B Neuropsychiatr Genet. 2008 Oct 5;147B(7):1301-5. doi: 10.1002/ajmg.b.30735.
In this report, we present results of a genome-wide linkage scan using as a phenotype the number of externalizing symptoms associated with alcohol use disorders. Subjects were collected by the Collaborative Study on the Genetics of Alcoholism project from families in which at least three first degree relatives were affected by alcohol dependence. We use a novel non-parametric regression method based on kernel smoothing for our analysis. We report a statistically significant linkage close to the ADH gene cluster on Chromosome 4. We also obtain evidence for epistatic interaction between a region on Chromosome 1 and one on Chromosome 15. Although alcoholism as a covariate does not have any effect on the linkage scan, it has an effect on the epistatic interaction.
在本报告中,我们呈现了一项全基因组连锁扫描的结果,该扫描将与酒精使用障碍相关的外化症状数量作为一种表型。研究对象由酒精中毒遗传学合作研究项目从至少有三名一级亲属受酒精依赖影响的家庭中收集。我们使用一种基于核平滑的新型非参数回归方法进行分析。我们报告了在4号染色体上靠近乙醇脱氢酶(ADH)基因簇处存在具有统计学意义的连锁。我们还获得了1号染色体上一个区域与15号染色体上一个区域之间上位性相互作用的证据。尽管酒精中毒作为一个协变量对连锁扫描没有任何影响,但它对上位性相互作用有影响。