Porjesz Bernice, Almasy Laura, Edenberg Howard J, Wang Kongming, Chorlian David B, Foroud Tatiana, Goate Alison, Rice John P, O'Connor Sean J, Rohrbaugh John, Kuperman Samuel, Bauer Lance O, Crowe Raymond R, Schuckit Marc A, Hesselbrock Victor, Conneally P Michael, Tischfield Jay A, Li Ting-Kai, Reich Theodore, Begleiter Henri
Department of Psychiatry, State University of New York, Health Science Center, Brooklyn, NY 11203, USA.
Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3729-33. doi: 10.1073/pnas.052716399. Epub 2002 Mar 12.
Human brain oscillations represent important features of information processing and are highly heritable. A common feature of beta oscillations (13-28 Hz) is the critical involvement of networks of inhibitory interneurons as pacemakers, gated by gamma-aminobutyric acid type A (GABA(A)) action. Advances in molecular and statistical genetics permit examination of quantitative traits such as the beta frequency of the human electroencephalogram in conjunction with DNA markers. We report a significant linkage and linkage disequilibrium between beta frequency and a set of GABA(A) receptor genes. Uncovering the genes influencing brain oscillations provides a better understanding of the neural function involved in information processing.
人类大脑振荡代表信息处理的重要特征,且具有高度遗传性。β振荡(13 - 28赫兹)的一个共同特征是,抑制性中间神经元网络作为起搏器发挥关键作用,由A型γ-氨基丁酸(GABA(A))作用控制。分子遗传学和统计遗传学的进展使得人们能够结合DNA标记来研究诸如人类脑电图β频率等数量性状。我们报告了β频率与一组GABA(A)受体基因之间存在显著的连锁和连锁不平衡。揭示影响大脑振荡的基因有助于更好地理解信息处理所涉及的神经功能。