Horcajada Patricia, Serre Christian, Maurin Guillaume, Ramsahye Naseem A, Balas Francisco, Vallet-Regí María, Sebban Muriel, Taulelle Francis, Férey Gérard
Institut Lavoisier, UMR CNRS 8180, Université de Versailles St-Quentin en Yvelines, 45 Avenue des Etats-Unis, 78035 Versailles Cedex, France.
J Am Chem Soc. 2008 May 28;130(21):6774-80. doi: 10.1021/ja710973k. Epub 2008 May 3.
Flexible nanoporous chromium or iron terephtalates (BDC) MIL-53(Cr, Fe) or M(OH)[BDC] have been used as matrices for the adsorption and in vitro drug delivery of Ibuprofen (or alpha- p-isobutylphenylpropionic acid). Both MIL-53(Cr) and MIL-53(Fe) solids adsorb around 20 wt % of Ibuprofen (Ibuprofen/dehydrated MIL-53 molar ratio = 0.22(1)), indicating that the amount of inserted drug does not depend on the metal (Cr, Fe) constitutive of the hybrid framework. Structural and spectroscopic characterizations are provided for the solid filled with Ibuprofen. In each case, the very slow and complete delivery of Ibuprofen was achieved under physiological conditions after 3 weeks with a predictable zero-order kinetics, which highlights the unique properties of flexible hybrid solids for adapting their pore opening to optimize the drug-matrix interactions.
柔性纳米多孔铬或铁的对苯二甲酸酯（BDC）MIL-53（Cr，Fe）或M(OH)[BDC]已被用作布洛芬（或α-对异丁基苯基丙酸）吸附和体外药物递送的基质。MIL-53（Cr）和MIL-53（Fe）固体均吸附约20 wt%的布洛芬（布洛芬/脱水MIL-53摩尔比 = 0.22(1)），这表明插入药物的量不取决于杂化骨架的组成金属（Cr，Fe）。文中给出了填充布洛芬的固体的结构和光谱表征。在每种情况下，在生理条件下3周后，布洛芬以可预测的零级动力学实现了非常缓慢且完全的释放，这突出了柔性杂化固体独特的性质，即能够调整其孔径以优化药物 - 基质相互作用。
