Francis Megan E, Uriel Shiri, Brey Eric M
Pritzker Institute of Biomedical Science and Engineering, Illinois Institute of Technology, Chicago, IL 60616, USA.
Tissue Eng Part B Rev. 2008 Mar;14(1):19-32. doi: 10.1089/teb.2007.0115.
The success of many therapies in regenerative medicine requires the ability to control the formation of stable vascular networks within tissues. The formation of new blood vessels, or neovascularization, is mediated, in part, by interactions between endothelial cells (ECs) and insoluble factors in the extracellular microenvironment. These interactions are determined by the chemical, physical, and mechanical properties of the matrix. Understanding how extracellular matrices (ECMs) and synthetic scaffolds influence neovascularization can contribute to the fundamental knowledge of normal and diseased tissue physiology and can be used to guide the design of new therapies. The goal of this review is to provide an overview of the complex role EC-matrix interactions play in neovascularization. A particular emphasis is placed on presenting differences in two subsets of ECM, basement membranes and stromal matrices, and identification of the properties of these matrices that define their biological functions. Attempts to apply information about EC-ECM interactions to enhance vascularization of synthetic materials are presented, and areas in need of further research are identified throughout this review. Our understanding of the role EC-matrix interactions play in neovascularization remains limited, but continued progress in this area could be of significant benefit to the design of clinically applicable engineered tissues.
再生医学中许多疗法的成功需要具备控制组织内稳定血管网络形成的能力。新血管的形成，即新生血管形成，部分是由内皮细胞（ECs）与细胞外微环境中的不溶性因子之间的相互作用介导的。这些相互作用由基质的化学、物理和机械特性决定。了解细胞外基质（ECMs）和合成支架如何影响新生血管形成，有助于深入了解正常和患病组织生理学的基础知识，并可用于指导新疗法的设计。本综述的目的是概述EC-基质相互作用在新生血管形成中所起的复杂作用。特别强调介绍ECM的两个子集，即基底膜和基质，之间的差异，并确定这些基质中定义其生物学功能的特性。本文还介绍了应用有关EC-ECM相互作用的信息来增强合成材料血管化的尝试，并在整个综述中确定了需要进一步研究的领域。我们对EC-基质相互作用在新生血管形成中所起作用的理解仍然有限，但该领域的持续进展可能对临床适用的工程组织的设计具有重大益处。
