Franks N P, Lieb W R
Biophysics Section, Blackett Laboratory, Imperial College of Science, Technology & Medicine, London, U.K.
Alcohol Alcohol Suppl. 1991;1:197-202.
We have discovered a novel potassium current in an identified molluscan neuron which is activated at surgical levels of volatile general anaesthetics. The current is not significantly voltage-gated and persists for as long as the anaesthetic is present. The anaesthetic response is completely reversibly and saturates at low anaesthetic partial pressures. The current is absent in surrounding neurons.
我们在一种已明确的软体动物神经元中发现了一种新型钾电流,该电流在挥发性全身麻醉药的手术浓度水平下被激活。这种电流并非显著的电压门控电流,并且只要麻醉药存在就会持续存在。麻醉反应完全可逆,且在低麻醉分压下达到饱和。周围神经元中不存在这种电流。