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[血管加压素对神经元膜的一种新作用机制]

[A new mechanism of action of vasopressin on the neuronal membrane].

作者信息

Artem'ev I Iu, Darinskiĭ Iu A, Sologub M I, Lozhkina T K

出版信息

Biull Eksp Biol Med. 1991 Feb;111(2):115-6.

PMID:1649650
Abstract

It is shown in this work that vasopressin at the concentrations of 1 x 10(-16) to 1 x 10(-6) mol/l decreased statistically significant the amplitude of the electrosensitive sodium and calcium ionic currents of the mollusc's Lymnaea stagnalis neuronal membrane. This peptide increased the amplitude of the fast potassium current at the concentration of 1 x 10(-16) and 1 x 10(-15) mol/l. It decreased the fast potassium current and did not change the slow potassium current at the concentrations more than 1 x 10(-9) mol/l.

摘要

这项研究表明,浓度为1×10⁻¹⁶至1×10⁻⁶摩尔/升的血管加压素能使软体动物椎实螺神经元膜的电敏感钠和钙离子电流幅度在统计学上显著降低。该肽在浓度为1×10⁻¹⁶和1×10⁻¹⁵摩尔/升时能增加快速钾电流的幅度。在浓度高于1×10⁻⁹摩尔/升时,它会降低快速钾电流,而对缓慢钾电流没有影响。

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