Wood W G, Schroeder F, Rao A M
VA Medical Center, GRECC, Minneapolis, MN 55417.
Alcohol Alcohol Suppl. 1991;1:221-5.
Ethanol both in vitro and in vivo has been shown to affect membrane bulk lipids and it had been previously proposed that such effects may explain sensitivity and tolerance to ethanol. There has been however, criticism of the membrane bulk lipid hypothesis and interest in the role of lipids as a site of the effects of ethanol has declined. This change in how lipids are viewed may have been premature. Several groups including work of our laboratory have shown in the past few years that ethanol has a very pronounced effect on membrane lipids but that these effects are restricted to specific domains of the membrane. This paper will discuss how ethanol affects membrane domains and mechanisms that may be involved in the regulation of lipid domains with emphasis on cholesterol domains. Discussion will also cover how lipid domains interact with protein organization and function.
乙醇在体外和体内均已被证明会影响膜中的大量脂质，并且此前有人提出，此类影响可能解释了对乙醇的敏感性和耐受性。然而，膜大量脂质假说受到了批评，人们对脂质作为乙醇作用位点的作用的兴趣也有所下降。这种对脂质看法的转变可能为时过早。包括我们实验室的工作在内，几个研究团队在过去几年中表明，乙醇对膜脂质有非常显著的影响，但这些影响仅限于膜的特定区域。本文将讨论乙醇如何影响膜区域以及可能参与脂质区域调节的机制，重点是胆固醇区域。讨论还将涵盖脂质区域如何与蛋白质的组织和功能相互作用。
