Maruyama K, Okazaki I, Takagi T, Ishii H
Clinical Research Unit, National Institute on Alcoholism, Kurihama National Hospital, Kanagawa, Japan.
Alcohol Alcohol Suppl. 1991;1:369-74.
Serum levels of type IV collagen and hepatic type IV collagenase activity, as markers for formation and degradation respectively of basement membrane collagen (type IV collagen) in liver, were measured in patients with various alcoholic liver diseases. Development of alcoholic liver fibrosis seems to be due to both increased formation and decreased degradation of basement membrane collagen. Both measurements of type IV collagenase activity and serum level of type IV collagen were assumed to be useful to predict irreversible state of hepatic fibrosis.
在患有各种酒精性肝病的患者中，检测了血清IV型胶原蛋白水平和肝IV型胶原酶活性，分别作为肝脏基底膜胶原蛋白（IV型胶原蛋白）形成和降解的标志物。酒精性肝纤维化的发展似乎是由于基底膜胶原蛋白的形成增加和降解减少所致。IV型胶原酶活性测定和IV型胶原蛋白血清水平测定均被认为有助于预测肝纤维化的不可逆状态。
