酒精偏好型大鼠对乙醇对多巴胺能系统影响的遗传敏感性。

Genetic sensitivity to effect of ethanol on dopaminergic system in alcohol preferring rats.

作者信息

Fadda F, Colombo G, Gessa G L

机构信息

Department of Neurosciences, University of Cagliari, Italy.

出版信息

Alcohol Alcohol Suppl. 1991;1:439-42.

PMID:1845574

Abstract

The effect of ethanol (etOH) on dopamine (DA) metabolism in the caudate nucleus (CN), olfactory tubercle (OT) and medial prefrontal cortex (MPFC) was compared in 2 selectively bred lines of rats, one etOH-preferring (sP) and the other -non preferring (sNP). EtOH (2 g/kg per os), administered 60 min before killing, caused a significant increase in concentrations of the DA metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), and reduced DA levels in CN and OT in sNP rats. On the other hand in sP rats, etOH increased the content of DA metabolites in all the 3 areas analyzed. These changes induced by etOH in DA metabolism were significantly greater in sP than in sNP rats. The above data indicate that sP rats have a genetic high sensitivity to etOH effect on DA metabolism probably linked to etOH preference.

摘要

在两个选择性育种的大鼠品系中比较了乙醇（etOH）对尾状核（CN）、嗅结节（OT）和内侧前额叶皮质（MPFC）中多巴胺（DA）代谢的影响，一个是乙醇偏好品系（sP），另一个是非偏好品系（sNP）。在处死前60分钟经口给予乙醇（2克/千克），导致sNP大鼠的DA代谢产物3,4 - 二羟基苯乙酸（DOPAC）和高香草酸（HVA）浓度显著增加，且CN和OT中的DA水平降低。另一方面，在sP大鼠中，乙醇增加了所有三个分析区域中DA代谢产物的含量。乙醇诱导的DA代谢变化在sP大鼠中比在sNP大鼠中显著更大。上述数据表明，sP大鼠对乙醇对DA代谢的影响具有遗传高敏感性，这可能与乙醇偏好有关。