Fadda F, Argiolas A, Melis M R, Serra G, Congia S
Boll Soc Ital Biol Sper. 1980 Dec 30;56(24):2559-63.
Acute oral administration of ethanol (3.2g/kg) to rats increased (DOPAC) levels in the caudate nucleus, but had no effect on DOPAC levels in the substantia nigra and frontal cortex and failed to modify dopamine content in any of the above areas. On the other hand, the administration of the same dose of ethanol to rats which had been chronically treated with ethanol (3.2g/kg daily for 60 days), produced a decrease of DA content and a parallel increase of DOPAC levels in all areas studied. In chronically treated rats, 24 hrs after last ethanol administration dopamine levels in the frontal cortex were 60% higher than in controls. The results suggest that ethanol administration causes dopamine release in different brain areas.
给大鼠急性口服乙醇（3.2克/千克）会增加尾状核中的（3,4-二羟基苯乙酸，DOPAC）水平，但对黑质和额叶皮质中的DOPAC水平没有影响，并且未能改变上述任何区域的多巴胺含量。另一方面，给长期用乙醇治疗的大鼠（每天3.2克/千克，持续60天）给予相同剂量的乙醇，会使所有研究区域的多巴胺含量降低，同时DOPAC水平平行升高。在长期治疗的大鼠中，最后一次给予乙醇24小时后，额叶皮质中的多巴胺水平比对照组高60%。结果表明，给予乙醇会导致不同脑区的多巴胺释放。
