Govindarajan Gurushankar, Alpert Martin A, Tejwani Lokesh
Division of Cardiology, University of Missouri-Columbia, School of Medicine, Columbia, MO 65212, USA.
Am J Med. 2008 May;121(5):366-70. doi: 10.1016/j.amjmed.2008.01.032.
The prevalence of obesity is increasing rapidly in both industrialized and developing nations. Obesity causes complex metabolic, endocrine, and hemodynamic changes that may lead to adverse cardiovascular outcomes such as coronary heart disease and congestive heart failure. Adipose tissue is no longer considered to be an inert organ of energy storage, but in fact possesses important endocrine and metabolic functions that are closely involved in energy homeostasis. During the past decade, our understanding of the unique pathophysiologic changes that occur with obesity has rapidly grown. This review discusses our current understanding of the endocrine and metabolic effects of fat and their potential relation to cardiovascular disease.
肥胖症在工业化国家和发展中国家的患病率都在迅速上升。肥胖会引发复杂的代谢、内分泌和血液动力学变化，这些变化可能导致不良的心血管后果，如冠心病和充血性心力衰竭。脂肪组织不再被认为是一个单纯的能量储存惰性器官，实际上它具有重要的内分泌和代谢功能，与能量平衡密切相关。在过去十年中，我们对肥胖所伴随的独特病理生理变化的理解迅速增加。这篇综述讨论了我们目前对脂肪的内分泌和代谢作用及其与心血管疾病潜在关系的理解。
