单侧纹状体内注射6-羟基多巴胺后对化学、热和机械刺激的伤害性行为反应
Nociceptive behavioral responses to chemical, thermal and mechanical stimulation after unilateral, intrastriatal administration of 6-hydroxydopamine.
作者信息
Chudler Eric H, Lu Ying
机构信息
Department of Bioengineering, University of Washington, Seattle, WA, USA.
出版信息
Brain Res. 2008 Jun 5;1213:41-7. doi: 10.1016/j.brainres.2008.03.053. Epub 2008 Apr 8.
Abstract
The basal ganglia are involved not only with motor processes such as posture, pre-movement planning and movement initiation, but also with the processing and modulation of nociceptive somatosensory information. In the current studies, unilateral, intrastriatal 6-hydroxydopamine (6-OHDA) was used to investigate how dopamine depletion alters nociceptive behavioral responses to chemical, thermal and mechanical stimulation in rats. Compared to control rats injected with intrastriatal saline, rats depleted of dopamine displayed increased nociceptive responses to chemical stimulation of the face and hyperalgesic responses to thermal stimulation of the hind paw without alterations in rearing behavior or body weight gain. Minor changes were observed in the response to mechanical stimulation of the hind paws and face. These data provide further evidence that the dopaminergic nigrostriatal pathway plays a role in the modulation of nociceptive information.
摘要
基底神经节不仅参与诸如姿势、运动前计划和运动发起等运动过程，还参与伤害性躯体感觉信息的处理和调节。在当前的研究中，使用单侧纹状体内注射6-羟基多巴胺（6-OHDA）来研究多巴胺耗竭如何改变大鼠对化学、热和机械刺激的伤害性行为反应。与注射纹状体内生理盐水的对照大鼠相比，多巴胺耗竭的大鼠对脸部化学刺激的伤害性反应增加，对后爪热刺激的痛觉过敏反应增加，而在竖毛行为或体重增加方面没有改变。在后爪和脸部的机械刺激反应中观察到微小变化。这些数据进一步证明多巴胺能黑质纹状体通路在伤害性信息的调节中起作用。
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