González A, Ventura-Juncá P
Departamento de Pediatría, Hospital Clínico, Universidad Católica de Chile.
Rev Chil Pediatr. 1991 Nov-Dec;62(6):354-8.
We have studied the incidence of patent ductus arteriosus (PDA), its clinical features and hemodynamic significance in 715 newborns < 2,000 g admitted to our nursery between 1978-1988. Among 566 in borns, 100 (18%) met clinical diagnostic criteria for PDA. Incidence of PDA by birth weight (BW) was: 17/88 (20%) for BW < 1,000 g; 57/179 (32%) for BW 1,000-1,499 g; and 26/299 (9%) for BW 1,500-1,999 g. PDA was considered hemodynamically significant (HS PDA) in 57 of the 100 babies with PDA, this was found to happen more frequently in smaller babies: 17/17 (100%) with BW < 1,000 g; 30/57 (52.6%) when BW was 1,000-1,499 g; and 10/26 (38.5%) for BW 1,500-1,999 g. Both incidence of PDA and percentage of HS PDA were significantly higher in preterms < 1,500 g (p < 0.01 and < 0.001 respectively). Among 149 outborns, 45 (30%) had PDA, the incidence by birth weight was: 7/17 (41%) in < 1,000 g; 27/70 (39%) in 1,000-1,499 g; and 11/62 (18%) for 1,500-1,999 g. The clinical findings and conditions more frequently found associated with HS PDA were: tachycardia (72%), bounding pulses (67%) and need of ventilatory support (64%), and 89% of these patients had some evidence of pulmonary disease, usually hyaline membrane disease (60%).
我们研究了1978年至1988年间入住我院新生儿重症监护室的715例体重小于2000克新生儿的动脉导管未闭（PDA）发病率、临床特征及其血液动力学意义。在566例足月儿中，100例（18%）符合PDA的临床诊断标准。按出生体重（BW）划分的PDA发病率为：体重小于1000克的患儿中17/88（20%）；体重1000 - 1499克的患儿中57/179（32%）；体重1500 - 1999克的患儿中26/299（9%）。100例患有PDA的婴儿中有57例被认为具有血液动力学意义（HS PDA），发现这种情况在较小的婴儿中更常见：体重小于1000克的患儿中17/17（100%）；体重1000 - 1499克时为30/57（52.6%）；体重1500 - 1999克时为10/26（38.5%）。体重小于1500克的早产儿中PDA发病率和HS PDA百分比均显著更高（分别为p < 0.01和< 0.001）。在149例早产儿中，45例（30%）患有PDA，按出生体重划分的发病率为：小于1000克的患儿中7/17（41%）；1000 - 1499克的患儿中27/70（39%）；1500 - 1999克的患儿中11/62（18%）。与HS PDA相关的更常见临床发现和情况为：心动过速（72%）、脉搏洪大（67%）和需要通气支持（64%），并且这些患者中有89%有一些肺部疾病的证据，通常为透明膜病（60%）。
