肠道特异性上皮内淋巴细胞生命历程中的胸腺篇章。
The thymus chapter in the life of gut-specific intra epithelial lymphocytes.
作者信息
Cheroutre Hilde, Lambolez Florence
机构信息
Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9240 Athena Circle, La Jolla, CA 92037, USA.
出版信息
Curr Opin Immunol. 2008 Apr;20(2):185-91. doi: 10.1016/j.coi.2008.03.009. Epub 2008 May 2.
Abstract
The intestinal intraepithelial lymphocytes (IEL) represent multi-lineage T cell populations. In addition to a major gammadeltaTCR(+) T cell subset, many IEL express alphabetaTCRs and they can be separated into alphabeta sublineages. Some TCRalphabeta(+)IEL have characteristics in common with conventional TCRalphabeta(+)T cells whereas others share an unconventional phenotype with their TCRgammadelta(+) counterparts. Because the latter are enriched for autoreactive TCRs and can be generated in the absence of a thymus, it has long been postulated that some IEL subsets develop locally in the intestine. Several new data however, indicate that under physiological conditions, IEL require a thymic education that directs lineage commitment and functional differentiation. This review will discuss the contributions of the thymus in shaping the various intestinal IEL sublineages.
摘要
肠道上皮内淋巴细胞（IEL）代表多谱系T细胞群体。除了主要的γδTCR(+) T细胞亚群外，许多IEL表达αβTCR，并且它们可被分为αβ亚谱系。一些TCRαβ(+)IEL具有与传统TCRαβ(+)T细胞相同的特征，而其他IEL则与其TCRγδ(+)对应物具有非传统表型。由于后者富含自身反应性TCR，并且可以在没有胸腺的情况下产生，长期以来人们一直推测某些IEL亚群在肠道中局部发育。然而一些新数据表明，在生理条件下，IEL需要胸腺的“教育”来指导谱系定向和功能分化。本综述将讨论胸腺在塑造各种肠道IEL亚谱系中的作用。
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本文引用的文献
1
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Immunity. 2008 Feb;28(2):149-59. doi: 10.1016/j.immuni.2008.01.005.
2
Lineage diversion of T cell receptor transgenic thymocytes revealed by lineage fate mapping.通过谱系命运图谱揭示T细胞受体转基因胸腺细胞的谱系分化
PLoS One. 2008 Jan 30;3(1):e1512. doi: 10.1371/journal.pone.0001512.
3
MHC-restricted T cell receptor signaling is required for alpha beta TCR replacement of the pre T cell receptor.MHC 限制性 T 细胞受体信号传导是前 T 细胞受体的αβTCR 替代所必需的。
Eur J Immunol. 2008 Feb;38(2):391-9. doi: 10.1002/eji.200737054.
4
Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium.1-磷酸鞘氨醇在淋巴细胞向肠道上皮细胞迁移调控中的依赖性
J Exp Med. 2007 Oct 1;204(10):2335-48. doi: 10.1084/jem.20062446. Epub 2007 Sep 17.
5
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J Immunol. 2007 Apr 1;178(7):4230-9. doi: 10.4049/jimmunol.178.7.4230.
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Curr Opin Immunol. 2007 Apr;19(2):169-75. doi: 10.1016/j.coi.2007.01.002. Epub 2007 Feb 8.
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J Immunol. 2007 Jan 15;178(2):757-64. doi: 10.4049/jimmunol.178.2.757.
10
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